CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

@inproceedings{Sennlaub2013CCR2MI,
  title={CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice},
  author={Florian Sennlaub and Constance Auvynet and Bertrand Calippe and Sophie Lavalette and Lucie Poupel and Shulong Justin Hu and Elisa Dominguez and Serge Camelo and Olivier Levy and Elodie Guyon and Noah Saederup and Israel F. Charo and Nico Van Rooijen and Emeline F. Nandrot and Jean-Louis Bourges and Francine B{\'e}har-Cohen and Jos{\'e}-Alain Sahel and Xavier Guillonneau and William Raoul and Christophe Combadi{\`e}re},
  booktitle={EMBO molecular medicine},
  year={2013}
}
Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CCR2(+) inflammatory monocyte infiltration in patients. Using age- and light-induced subretinal inflammation and photoreceptor degeneration in Cx3cr1 knockout mice, we show that subretinal Cx3cr1… CONTINUE READING
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CX3CR1 deficient macrophages present an impaired clearance from the subretinal space

  • OE Levy, BE Calippe, +5 authors F Sennlaub
  • ARVO Meeting Abstr
  • 2011
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