CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.

@article{Lin2008CCR2MD,
  title={CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.},
  author={Kaifeng Lisa Lin and Yasushi Suzuki and Hideki Nakano and Elizabeth A Ramsburg and Michael D Gunn},
  journal={Journal of immunology},
  year={2008},
  volume={180 4},
  pages={2562-72}
}
Infection with pathogenic influenza virus induces severe pulmonary immune pathology, but the specific cell types that cause this have not been determined. We characterized inflammatory cell types in mice that overexpress MCP-1 (CCL2) in the lungs, then examined those cells during influenza infection of wild-type (WT) mice. Lungs of both naive surfactant protein C-MCP mice and influenza-infected WT mice contain increased numbers of CCR2(+) monocytes, monocyte-derived DC (moDC), and exudate… CONTINUE READING

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