CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.

@article{Kunkel2003CCR10EI,
  title={CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.},
  author={E. Kunkel and Chang H. Kim and N. Lazarus and M. Vierra and D. Soler and E. Bowman and E. Butcher},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 7},
  pages={
          1001-10
        }
}
The dissemination of IgA-dependent immunity between mucosal sites has important implications for mucosal immunoprotection and vaccine development. Epithelial cells in diverse gastrointestinal and nonintestinal mucosal tissues express the chemokine MEC/CCL28. Here we demonstrate that CCR10, a receptor for MEC, is selectively expressed by IgA Ab-secreting cells (large s/cIgA(+)CD38(hi)CD19(int/-)CD20(-)), including circulating IgA(+) plasmablasts and almost all IgA(+) plasma cells in the salivary… Expand
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References

SHOWING 1-10 OF 46 REFERENCES
The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells
TLDR
Thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node, thus helping define and segregate the intestinal immune response. Expand
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
TLDR
Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Expand
Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues1 2
TLDR
An important role for MEC is suggested in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs, because it attracts eosinophils in addition to memory lymphocyte subsets. Expand
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
TLDR
The results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues. Expand
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
TLDR
It is concluded that IgA+ cells in the gut lamina propria are generated in situ from B220+IgM+ lymphocytes, as they still express both AID and transcripts from circular DNA that has been ‘looped-out' during CSR. Expand
Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues.
TLDR
The origins of immunoglobulin-containing cells in intestinal, respiratory, mammary, and genital tissues were studied in CBA/J female mice by using an adoptive lymphocyte transfer method and data support the concept of a common mucosal immunologic system. Expand
The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System1
TLDR
It is suggested that the selective expression of TECK in the small bowel underlie the homing of CCR9+ intestinal memory T cells to theSmall bowel rather than to the colon, which implies a segregation of small intestinal from colonic immune responses. Expand
Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue.
TLDR
It is found that human MAdCAM-1, as in the mouse, is expressed in a tissue-selective manner and may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity. Expand
Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics
TLDR
It is concluded that the lamina propria B‐ cell compartment consists mainly of B‐cell blasts and plasma cells but also has scattered, small sIgA+ cells that can proliferate in response to CD40 ligation and may therefore function as local memory cells for recall antigens. Expand
Immune Surveillance and Effector Functions of CCR10+ Skin Homing T Cells
TLDR
Homing and chemokine receptor coexpression studies suggest that the CLA+/CCR10+ memory CD4 T cell population contains members that have access to both secondary lymphoid organ and skin compartments and can act as both “central” and “effector” memory T cells. Expand
...
1
2
3
4
5
...