CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome.

@article{Vielhauer2004CCR1BR,
  title={CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome.},
  author={Volker Vielhauer and E. Douglas Berning and V{\'a}clav Eis and Matthias Kretzler and Stephan Segerer and Frank Strutz and Richard Horuk and Hermann-Josef Gr{\"o}ne and Detlef Schl{\"o}ndorff and Hans-Joachim Anders},
  journal={Kidney international},
  year={2004},
  volume={66 6},
  pages={
          2264-78
        }
}
BACKGROUND CC chemokines mediate leukocyte infiltration into inflamed tissue. We have recently shown that blockade of the CC chemokine receptor CCR1 reduces interstitial inflammation and fibrosis in murine obstructive nephropathy. However, it is not known whether CCR 1 blockade is protective in progressive renal injury associated with severe proteinuria. We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental… CONTINUE READING
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