CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling.

@article{Kato2013CCR1CCL5IP,
  title={CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling.},
  author={Taku Kato and Yasunori Fujita and Keita Nakane and Kosuke Mizutani and Riyako Terazawa and Hidetoshi Ehara and Yusuke Kanimoto and Toshio Kojima and Yoshinori Nozawa and Takashi Deguchi and Masafumi Ito},
  journal={Cytokine},
  year={2013},
  volume={64 1},
  pages={
          251-7
        }
}
Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemokine (C-C motif) ligand 5 (CCL5), in taxane-resistant CRPC using paclitaxel-resistant prostate cancer cells (PC3PR) established from PC3 cells. We found that the expression levels… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS