CCR 5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp 120

@inproceedings{Wang1998CCR5C,
  title={CCR 5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp 120},
  author={W Wang and Tim Dudek and Y Zhao and Hunter Brumblay and Max Essex and T Lee},
  year={1998}
}
The seven-transmembrane CCR5 was recently found to double as a coreceptor for a genetically diverse family of human and nonhuman primate lentiviruses. Paradoxically, the main region of the envelope protein believed to be involved in CCR5 utilization was mapped to hypervariable region 3, or V3, of the envelope glycoprotein gp120. In this study, we addressed the question of whether functional convergence in CCR5 utilization is mediated by certain V3 residues that are highly conserved among HIV… CONTINUE READING

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