CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b.

@article{Blom2003CCP14OT,
  title={CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b.},
  author={Anna M. Blom and Lena Kask and Bj{\"o}rn Dahlb{\"a}ck},
  journal={Molecular immunology},
  year={2003},
  volume={39 10},
  pages={
          547-56
        }
}
C4b-binding protein (C4BP) is a potent regulator of the complement system because it strongly inhibits the classical pathway of complement. Furthermore, C4BP serves as a cofactor to factor I (FI) in the cleavage of fluid phase C3b and can, therefore, influence the alternative pathway of complement. The major form of C4BP in plasma consists of seven identical alpha-chains and one beta-chain. Both types of subunits are composed of complement control protein (CCP) domains, eight such domains make… CONTINUE READING
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