CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

@inproceedings{Hou2013CCN4II,
  title={CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts},
  author={Chun-han Hou and Chih-Hsin Tang and C T Hsu and S. H. Hou and Ju-Fang Liu},
  booktitle={Arthritis research & therapy},
  year={2013}
}
INTRODUCTION Osteoarthritis (OA) is the most common degenerative joint disease that is involved in the degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regulation in the cartilage of patients with osteoarthritis. Previous studies have shown that CCN4 might be associated with the pathogenesis of… CONTINUE READING