CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression

@inproceedings{Chen2017CCN3PE,
  title={CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression},
  author={Po-Chun Chen and Huai-Ching Tai and Tien-Huang Lin and Shih-Wei Wang and Chih-Yang Lin and Chia-Chia Chao and Hong-Jeng Yu and Yu-Chieh Tsai and Yu Wei Lai and Chiao-Wen Lin and Chih-Hsin Tang},
  booktitle={Oncotarget},
  year={2017}
}
Epithelial-mesenchymal transition (EMT) has received considerable attention as a conceptual paradigm for explaining metastatic behavior during cancer progression. NOV/CCN3 is a matrix-associated protein involved in many cellular functions. Previous studies have shown that CCN3 expression is upregulated in prostate cancer (PCa) cells and in PCa patients. In this study, we have provided evidence of tumor promoting effects of CCN3, which includes induction of epithelial-to-mesenchymal transition… CONTINUE READING

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