CCN3 impairs osteoblast and stimulates osteoclast differentiation to favor breast cancer metastasis to bone.

@article{Ouellet2011CCN3IO,
  title={CCN3 impairs osteoblast and stimulates osteoclast differentiation to favor breast cancer metastasis to bone.},
  author={V{\'e}ronique Ouellet and Kerstin Tiedemann and Anna Alexeyevna Mourskaia and Jenna E. Fong and Danh Tran-Thanh and Eitan Amir and Mark Clemons and Bernard Perbal and Svetlana V. Komarova and Peter M Siegel},
  journal={The American journal of pathology},
  year={2011},
  volume={178 5},
  pages={2377-88}
}
Bone is a preferred site for breast cancer metastasis, causing pain, fractures, spinal cord compressions, and hypercalcemia, all of which can significantly diminish the patient's quality of life. We identified CCN3 as a novel factor that is highly expressed in bone metastatic breast cancer cells from a xenograft mouse model and in bone metastatic lesions from patients with breast cancer. We demonstrate that CCN3 overexpression enhances the ability of weakly bone metastatic breast cancer cells… CONTINUE READING

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