CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis.

  title={CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis.},
  author={Tong Dang and Cristina Modak and Xiemei Meng and Jinbao Wu and R. Byron Narvaez and Jianyuan Chai},
  journal={Experimental cell research},
  volume={361 1},
TRAIL is one of the best anti-cancer molecules in our body. It kills a variety of cancer cells that are resistant to conventional chemotherapy, without causing much negative impact on normal cells, because its death receptors are almost exclusively found on cancer cells. However, some cancer cells are not sensitive to TRAIL treatment, even though they express its death receptors. A second molecule is needed to help TRAIL to complete its mission. Finding such molecules now becomes a top priority… CONTINUE READING


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