CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway.

Abstract

CCN1 (Cyr61) is a secreted matricellular protein, mediating angiogenesis and cell survival through interaction with integrins. Although CCN1 expression is induced in the heart during ischemia and pressure overload, its function in cardiac myocytes remains to be elucidated. We hypothesized that CCN1 may not only induce angiogenesis but may also have a direct… (More)

Topics

Cite this paper

@article{Yoshida2007CCN1PC, title={CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway.}, author={Yoshinori Yoshida and Kiyonori Togi and Hironobu Matsumae and Yasuhiro Nakashima and Yoji Kojima and Hiromi Yamamoto and Koh Ono and Tomoyuki Nakamura and Toru Kita and Makoto Tanaka}, journal={Biochemical and biophysical research communications}, year={2007}, volume={355 3}, pages={611-8} }