CCN1/CYR61: the very model of a modern matricellular protein

  title={CCN1/CYR61: the very model of a modern matricellular protein},
  author={Lester F. Lau},
  journal={Cellular and Molecular Life Sciences},
CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein that plays essential roles in cardiovascular development during embryogenesis, and regulates inflammation, wound healing and fibrogenesis in the adult. Aberrant CCN1 expression is associated with myriad pathologies, including various cancers and diseases associated with chronic inflammation. CCN1 promotes diverse and sometimes opposing cellular responses, which can be ascribed, as least in part, to disparate… CONTINUE READING


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