CCN proteins and cancer: two to tango.

@article{Bleau2005CCNPA,
  title={CCN proteins and cancer: two to tango.},
  author={Anne Marie Bleau and Nathalie Planque and Bernard Perbal},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2005},
  volume={10},
  pages={
          998-1009
        }
}
The CCN genes encode secreted proteins, associated to the extracellular matrix. They are involved in diverse biological processes such as regulation of cell- adhesion, migration, proliferation, differentiation and survival. They play important roles in pregnancy, development, angiogenesis, wound repair and inflammation. Several lines of evidence support a role for CCN genes in fibrotic disorders and tumorigenesis. We will focus our attention in this review on two CCN proteins: CCN1 and CCN3… 
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Role of the CCN protein family in cancer
TLDR
The CCN protein family is composed of six matricellular proteins, which serve regulatory roles rather than structural roles in the extracellular matrix, and function either through binding to integrin receptors or by regulating the expression and activity of growth factors and cytokines.
The CCN family proteins in carcinogenesis.
TLDR
A precise knowledge about the pathophysiological activities including signaling pathways of CCN proteins would be helpful to identify molecular targets in order to design therapeutic strategies in the management of cancer.
Regulation of the CCN genes by vitamin D: A possible adjuvant therapy in the treatment of cancer and fibrosis.
CCN6 (WISP3) as a New Regulator of the Epithelial Phenotype in Breast Cancer
TLDR
This review will focus on the emerging role of CCN6 as a regulator of the epithelial phenotype and E-cadherin expression in the breast with special emphasis on the current knowledge regarding the function ofCCN6.
CCN family of proteins: critical modulators of the tumor cell microenvironment
TLDR
Because the CCN proteins further interact with other key proteins, like growth factors in the matrix, the balance is not only important but can vary dynamically with the physiological states of tumor cells and the surrounding normal cells.
CCN1: a novel inflammation-regulated biphasic immune cell migration modulator
TLDR
It is shown that CCN1 binds to various immune cells including T cells, B cells, NK cells, and monocytes, and that patients suffering from acute inflammation had enhanced serum levels ofCCN1.
The CCN family of proteins: structure–function relationships
The CCN family of genes: a perspective on CCN biology and therapeutic potential
TLDR
The CCN family of genes currently comprises six secreted proteins that are involved in mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types.
Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts
TLDR
Ex vivo effects of the profibrotic protein TGFbeta1 on dermal fibroblasts on protein and RNA expression of CCN3 and CCN2, as well as the related protein CCN1 are evaluated to suggest that alterations in CCN 2:CCN3 expression might be important in skin biology in vivo.
Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells
TLDR
It is proposed that contact with MSC-derived CCN1 leads to splicing and enhanced transcription ofCCN1 which further contributes to the translation of angiogenic factor CCN 1 in myeloma cells, supporting tumor viability and myel cancer bone disease.
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References

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