CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

Abstract

Mutations in CCM3/PDCD10 result in cerebral cavernous malformations (CCMs), a major cause of cerebral hemorrhage. Despite intense interest in CCMs, very little is known about the function of CCM3. Here, we report that CCM3 is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi… (More)
DOI: 10.1242/jcs.061341

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