BACKGROUND AND PURPOSE
Mutations in CCM2 (MGC4607 or malcavernin) cause familial cerebral cavernous malformation (CCM), an autosomal dominant neurovascular disease. Both the function of this molecule and the pathogenesis of the disease remain elusive.
We analyzed the mRNA expression of Ccm1 and Ccm2 in the embryonic and postnatal mouse brain by in… (More)
Figure 1. Ccm1 (A through F) and Ccm2 (A through F ) mRNA expression in embryonic mouse brain. Both genes are expressed in the ventricular zone (vz), in the developing cerebral cortex (Ctx), striatum (Str), hippocampal formation (Hip), thalamic (Th) and hypothalamic (HTh) nuclei, and the facial nucleus (n7n). Ccm1 mRNA is also expressed in the oculomotor nucleus (n3n) and the developing cerebellum (Cb). Images are consecutive sections derived from a single brain at embryonic day 16.5 (E16.5).