CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase

  title={CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase},
  author={Liraz Harel and B{\'a}rbara Nogueira Souza Costa and Marianna Tcherpakov and Marc Zapatka and Andr{\'e} Oberthuer and Loen M. Hansford and Milijana Vojvodic and Zehava Levy and Zhe-yu Chen and Francis B. S. Lee and Smadar Avigad and Isaac Yaniv and Leming Shi and Roland Eils and Matthias Hermann Fischer and Benedikt Brors and David R Kaplan and Mike Fainzilber},
The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism. Here, we show that CCM2, a gene product associated with cerebral cavernous malformations, interacts with the juxtamembrane region of TrkA via its phosphotyrosine binding (PTB) domain and mediates TrkA-induced death in diverse cell types. Both the PTB and Karet… CONTINUE READING
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A PP 2 A phosphatase high density interaction network identifies a novel striatininteracting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 ( CCM 3 ) protein

  • A. Gulino, A. Arcella, F. Giangaspero
  • Mol . Cell . Proteomics
  • 2009

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