CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation

@inproceedings{Draheim2015CCM2CCM3IS,
  title={CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation},
  author={Kyle M. Draheim and Xiao-Feng Li and Rong Zhang and Oriana S. Fisher and Giulia Villari and Titus J Boggon and David A Calderwood},
  booktitle={The Journal of cell biology},
  year={2015}
}
Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other neurological disorders. CCM2 binds CCM3, but the molecular basis of this interaction, and its functional significance, have not been elucidated. Here, we used x-ray crystallography and structure-guided mutagenesis to show that an α-helical LD-like motif within… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…