CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling

@inproceedings{Faurobert2013CCM1ICAP1CC,
  title={CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling},
  author={Eva Faurobert and Claire Rome and Justyna Lisowska and Sandra Manet-Dup{\'e} and Gw{\'e}nola Boulday and Marilyne Malbouyres and Martial Balland and A. S. Bouin and Michelle K{\'e}ramidas and Daniel Bouvard and Josep Batll{\'o} Coll and Florence Di Ruggiero and Elisabeth Tournier-Lasserve and Corinne Albiges-Rizo},
  booktitle={The Journal of cell biology},
  year={2013}
}
The endothelial CCM complex regulates blood vessel stability and permeability. Loss-of-function mutations in CCM genes are responsible for human cerebral cavernous malformations (CCMs), which are characterized by clusters of hemorrhagic dilated capillaries composed of endothelium lacking mural cells and altered sub-endothelial extracellular matrix (ECM). Association of the CCM1/2 complex with ICAP-1, an inhibitor of β1 integrin, prompted us to investigate whether the CCM complex interferes with… CONTINUE READING

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