CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.

@article{Lant2015CCM3STRIPAKPS,
  title={CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.},
  author={Benjamin Lant and Bin Yu and Marilyn Goudreault and Doug Holmyard and James D. R. Knight and Peter Xu and Linda Zhao and Kelly S Chin and Evan Wallace and Mei Zhen and Anne-Claude Gingras and W. Brent Derry},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={6449}
}
The mechanisms governing apical membrane assembly during biological tube development are poorly understood. Here, we show that extension of the C. elegans excretory canal requires cerebral cavernous malformation 3 (CCM-3), independent of the CCM1 orthologue KRI-1. Loss of ccm-3 causes canal truncations and aggregations of canaliculular vesicles, which form ectopic lumen (cysts). We show that CCM-3 localizes to the apical membrane, and in cooperation with GCK-1 and STRIPAK, promotes CDC-42… CONTINUE READING
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