CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder.

@article{Brown2012CCL3L1GC,
  title={CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder.},
  author={Amanda M. Brown and Ned Sacktor and Karen S. Marder and Bruce Cohen and Giovanni Schifitto and R L Skolasky and Jason A Creighton and Liping Guo and Justin C. Mcarthur},
  journal={Current biomarker findings},
  year={2012},
  volume={2012 2},
  pages={
          1-6
        }
}
BACKGROUND CCL3L1 copy number variation has been implicated as a marker for susceptibility and immunity to human immunodeficiency virus (HIV)-1 infection and its pathogenic sequelae. Some of these findings have been confirmed in several, but not all, subsequent independent cohort studies. A three-fold risk for the development of HIV-associated dementia was reported in individuals possessing a CCL3L1 copy number below the ethnic group median combined with a detrimental CCR5 genotype. With the… CONTINUE READING

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