CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus.

@article{Mamtani2008CCL3L1GS,
  title={CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus.},
  author={Manju Mamtani and B Rovin and Robin L. Brey and Jos{\'e} Tarc{\'i}sio Franco de Camargo and Hemant Kulkarni and M{\'o}nica Herrera and Pamela Correa and Steve Holliday and Juan-Manuel Anaya and Sunil K. Ahuja},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 8},
  pages={1076-83}
}
OBJECTIVES There is an enrichment of immune response genes that are subject to copy number variations (CNVs). However, there is limited understanding of their impact on susceptibility to human diseases. CC chemokine ligand 3 like-1 (CCL3L1) is a potent ligand for the HIV coreceptor, CC chemokine receptor 5 (CCR5), and we have demonstrated previously an association between CCL3L1-gene containing segmental duplications and polymorphisms in CCR5 and HIV/AIDS susceptibility. Here, we determined the… CONTINUE READING