CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

@article{Dolan2007CCL3L1AC,
  title={CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms},
  author={M. Dolan and H. Kulkarni and J. Camargo and Weijing He and Alison Smith and J. Anaya and T. Miura and F. Hecht and M. Mamtani and F. Pereyra and V. Marconi and A. Mangano and L. Sen and R. Bologna and R. Clark and S. A. Anderson and J. Delmar and R. O'Connell and A. Lloyd and J. Martin and S. S. Ahuja and B. Agan and B. Walker and S. Deeks and S. Ahuja},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={1324-1336}
}
  • M. Dolan, H. Kulkarni, +22 authors S. Ahuja
  • Published 2007
  • Biology, Medicine
  • Nature Immunology
  • Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease… CONTINUE READING
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