CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

@article{Dolan2007CCL3L1AC,
  title={CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms},
  author={Matthew J. Dolan and Hemant Kulkarni and Jos{\'e} Tarc{\'i}sio Franco de Camargo and Weijing He and Alison Smith and Juan-Manuel Anaya and Toshiyuki Miura and Frederick M. Hecht and Manju Mamtani and Florencia Pereyra and Vincent C. Marconi and Andrea M Mangano and Luisa Sen and Rosa Bologna and Robert A. Clark and Stephanie A. Anderson and Judith A Delmar and Robert J. O'Connell and Andrew T. Lloyd and Jeffrey W. Martin and Seema S. Ahuja and Brian K. Agan and Bruce D. Walker and Steven G. Deeks and Sunil K. Ahuja},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={1324-1336}
}
Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease… CONTINUE READING
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Fundamental insights from clinical studies

  • L. Abel, Casanova, J. L. Human genetics of infectious diseases
  • Semin. Immunol. 18, 327–329
  • 2006

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