CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance.

Abstract

Manipulation of regulatory T cell (Treg) migration by islet expression of the chemokine CCL22 prevents diabetes in NOD mice and delays recurrent autoimmunity in syngeneic islet transplants. We sought to determine whether attracting Tregs with CCL22 also prevents islet allograft rejection. Isolated Bl/6 mouse islets were transduced overnight with adenovirus… (More)
DOI: 10.3727/096368914X685249

Topics

  • Presentations referencing similar topics