CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity.

@article{Turnquist2007CCL21IE,
  title={CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity.},
  author={Hēth R Turnquist and Xuede Lin and Abdelkader Elbadawy Ashour and Michael Anthony Hollingsworth and Rakesh K. Singh and James E Talmadge and Joyce C. Solheim},
  journal={International journal of oncology},
  year={2007},
  volume={30 3},
  pages={631-9}
}
Chemokines are vital messengers that regulate immune cell activity. The chemokine CCL21 is normally expressed in secondary lymphoid organs and acts as a chemoattractant for several populations of immune cells. Herein, we report that intratumoral CCL21 administration recruited significant numbers of immune cells into murine pancreatic tumors and inhibited tumor growth. Detailed flow cytometric and confocal analysis of CCL21-treated tumor cell isolates revealed increased lymphoid-related… CONTINUE READING