CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups.

@article{Lisignoli2009CCL20CCR6CE,
  title={CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups.},
  author={Gina Lisignoli and Cristina Manferdini and Katia Codeluppi and Anna Piacentini and Francesco Grassi and Luca Cattini and Giuseppe Filardo and Andrea Facchini},
  journal={Journal of cellular physiology},
  year={2009},
  volume={221 1},
  pages={154-60}
}
Subchondral bone remodeling in osteoarthritis (OA) and rheumatoid arthritis (RA) is mainly characterized by the formation of osteophytes/fibrosis and by the presence of infiltrating cells associated to bone resorption. In this study we analyzed CC (cysteine cysteine motif) chemokine ligand (CCL)20 and CC chemokine receptor (CCR)6 function in subchondral bone tissue and osteoblasts isolated from OA and RA patients. CCL20/CCR6 expression was evaluated by immunohistochemical techniques in bone… CONTINUE READING

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