CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice.

  title={CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice.},
  author={Mich{\`e}le Doucet and Swaathi Jayaraman and Emily Swenson and Brittany Tusing and Kristy L Weber and Scott L. Kominsky},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={31 7},
CCL20 is a member of the macrophage inflammatory protein family and is reported to signal monogamously through the receptor CCR6. Although studies have identified the genomic locations of both Ccl20 and Ccr6 as regions important for bone quality, the role of CCL20/CCR6 signaling in regulating bone mass is unknown. By micro-computed tomography (μCT) and histomorphometric analysis, we show that global loss of Ccr6 in mice significantly decreases trabecular bone mass coincident with reduced… CONTINUE READING