CCL2 regulates angiogenesis via activation of Ets-1 transcription factor.

@article{Stamatovic2006CCL2RA,
  title={CCL2 regulates angiogenesis via activation of Ets-1 transcription factor.},
  author={Svetlana M. Stamatovic and Richard F. Keep and Marija Mostarica-Stojkovi{\'c} and Anuska V. Andjelkovic},
  journal={Journal of immunology},
  year={2006},
  volume={177 4},
  pages={
          2651-61
        }
}
Although recent studies have suggested that CC chemokine CCL2 may directly affect the angiogenesis, the signaling events involved in such regulation remain to be determined. This study investigated a potential signal mechanism involved in CCL2-induced angiogenesis. Our in vitro and in vivo (hemangioma model of angiogenesis) experiments confirmed earlier findings that CCL2 can induce angiogenesis directly. Using a gene array analysis, CCL2 was found to induce expression of several angiogenic… CONTINUE READING
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