CCL2 has similar excitatory effects to TNF-α in a subgroup of inflamed C-fiber axons

@inproceedings{Richards2011CCL2HS,
  title={CCL2 has similar excitatory effects to TNF-α in a subgroup of inflamed C-fiber axons},
  author={N. T. Richards and Thomas Batty and Andrew Dilley},
  booktitle={Journal of neurophysiology},
  year={2011}
}
Peripheral nerve inflammation can cause neuronal excitability changes that have been implicated in the pathogenesis of chronic pain. Although the neuroimmune interactions that lead to such physiological changes are unclear, in vitro studies suggest that the chemokine CCL2 may be involved. This in vivo study examines the effects of CCL2 on untreated and inflamed neurons and compares its effects with those of TNF-α. Extracellular recordings were performed in the anesthetized rat on isolated… CONTINUE READING

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