CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study

@article{McDermott2005CCL2PA,
  title={CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study},
  author={David H. McDermott and Qiong Yang and Sekar Kathiresan and L. Adrienne Cupples and Joseph M. Massaro and John F. Keaney and Martin G. Larson and Ramachandran S. Vasan and Joel N. Hirschhorn and Christopher J. O’Donnell and Philip M. Murphy and Emelia J. Benjamin},
  journal={Circulation},
  year={2005},
  volume={112},
  pages={1113-1120}
}
Background—Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. Methods and Results—We analyzed the association of genetic variation in the MCP-1 gene (CCL2) with prevalent myocardial infarction and serum MCP-1 levels in the community-based Framingham Heart Study Offspring Cohort (50% women; mean age, 62 years). MCP-1 levels and CCL2 genotypes were determined in 3236 and 1797… 

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References

SHOWING 1-10 OF 44 REFERENCES
Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness.
  • Y. Tabara, K. Kohara, T. Miki
  • Medicine
    Hypertension research : official journal of the Japanese Society of Hypertension
  • 2003
TLDR
Findings indicate that plasma MCP-1 is associated with carotid atherosclerosis.
Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes
TLDR
In a large cohort of patients with acute coronary syndromes, an elevated baseline level of MCP-1 was associated both with traditional risk factors for atherosclerosis as well as an increased risk for death or myocardial infarction, independent of baseline variables.
Atherosclerosis in Patients Infected With HIV Is Influenced by a Mutant Monocyte Chemoattractant Protein-1 Allele
TLDR
HIV-infected patients with the MCP-1–2518G allele have a 5-fold increased risk for atherosclerosis, as assessed by ultrasonography.
Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
TLDR
The findings demonstrate that MCP-1 is produced in isolated human adipocytes and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
Plasma monocyte chemoattractant protein-1 antigen levels and the risk of restenosis after coronary stent implantation.
TLDR
The study concludes that MCP-1 production at stented coronary arterial sites is associated with an increased risk for restenosis post stent implantation.
...
...