CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study

  title={CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study},
  author={David H. McDermott and Qiong Yang and Sekar Kathiresan and L. Adrienne Cupples and Joseph M. Massaro and John F. Keaney and Martin G. Larson and Ramachandran S. Vasan and Joel N. Hirschhorn and Christopher J. O’Donnell and Philip M. Murphy and Emelia J. Benjamin},
Background—Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. Methods and Results—We analyzed the association of genetic variation in the MCP-1 gene (CCL2) with prevalent myocardial infarction and serum MCP-1 levels in the community-based Framingham Heart Study Offspring Cohort (50% women; mean age, 62 years). MCP-1 levels and CCL2 genotypes were determined in 3236 and 1797… 

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