CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice.

  title={CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice.},
  author={Nitsan Maharshak and Gili Hart and Ehud Ron and Einat Zelman and Adi Sagiv and Nadir Arber and Eli Brazowski and Raanan Margalit and Eran Elinav and Idit Shachar},
  journal={Inflammatory bowel diseases},
  volume={16 9},
BACKGROUND Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM levels of CCL2 dramatically inhibit migration of T cells. The aim was to test whether subphysiological doses of CCL2 can ameliorate murine colitis and inflammation-induced… CONTINUE READING


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