CCL19 as an adjuvant for intradermal gene gun immunization in a Her2/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC

Abstract

The aim of this study was to evaluate the efficacy of the chemokine CCL19 (ELC) as an adjuvant for intradermal gene gun delivery of Her2/neu DNA and to investigate the role of B cells in CCL19-mediated enhancement of immune responses. Balb/c mice were immunized intramuscularly (i.m.) on days 1 and 15 with plasmid DNA (pDNA) (100 μg DNA) or intradermally (i… (More)
DOI: 10.1038/cgt.2012.78

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@article{NguyenHoai2012CCL19AA, title={CCL19 as an adjuvant for intradermal gene gun immunization in a Her2/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC}, author={Tam Nguyen-Hoai and Oliver Hohn and Milan Vu and Gerd Baldenhofer and M S Sayed Ahmed and Bernd Doerken and Steve Norley and Melanie Lipp and Alessandro Pezzutto and J{\"u}rgen Westermann}, journal={Cancer Gene Therapy}, year={2012}, volume={19}, pages={880-887} }