CCK1 antagonists: Design, Synthesis and Evaluation of N-Substituted Isobuyl-5-Hydroxy-5-Phenyl-Pyrrol-2- Ones as Adjunct to Opiates

@inproceedings{Lattmann2018CCK1AD,
  title={CCK1 antagonists: Design, Synthesis and Evaluation of N-Substituted Isobuyl-5-Hydroxy-5-Phenyl-Pyrrol-2- Ones as Adjunct to Opiates},
  author={Eric Lattmann},
  year={2018}
}
Introduction In terms of cholecystokinin-physiology, CCK8 is the most common peptide hormone, which is extensively found throughout the gastrointestinal tract and is also widely distributed through the nervous system [1,2]. Originally, cholecystokinin was discovered to cause contractions of the gallbladder [3]. It was then rediscovered as pancreozymin, triggering the release of pancreatic enzymes. Finally, it was confirmed that both peptides are identical [4]. Cholecystokinin acts as a… CONTINUE READING

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