CCK-releasing activity of rat intestinal secretion: effect of atropine and comparison with monitor peptide.

@article{Guan1990CCKreleasingAO,
  title={CCK-releasing activity of rat intestinal secretion: effect of atropine and comparison with monitor peptide.},
  author={Dongsheng Guan and Hideo Ohta and T Tawil and Rodger A. Liddle and Gary M. Green},
  journal={Pancreas},
  year={1990},
  volume={5 6},
  pages={677-84}
}
A bioassay for studying the cholecystokinin (CCK)-releasing activity of intraluminal protease-sensitive bioactive peptides was developed. In conscious rats, bile and pancreatic juice were chronically diverted from the proximal intestine to the ileum to cause chronic stimulation of CCK release and pancreatic protein secretion. CCK-releasing activity of test substances was assayed during transient inhibition of CCK release by intraduodenal sodium taurocholate (78 mumols/h). Intestinal secretion… CONTINUE READING