CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response

@article{Kim2007CCDC98IA,
  title={CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response},
  author={HongTae Kim and Jun Huang and Junjie Chen},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={710-715}
}
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain–containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control… CONTINUE READING
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