CCDC106 promotes non-small cell lung cancer cell proliferation

  title={CCDC106 promotes non-small cell lung cancer cell proliferation},
  author={Xiupeng Zhang and Qin Zheng and Chen Wang and Haijing Zhou and Guiyang Jiang and Y. Z. Miao and Yong Zhang and Yang Liu and Qingchang Li and Xueshan Qiu and Enhua Wang},
Coiled-coil domain containing (CCDC) family members enhance tumor cell proliferation, and high CCDC protein levels correlate with unfavorable prognoses. Limited research demonstrated that CCDC106 may promote the degradation of p53/TP53 protein and inhibit its transactivity. The present study demonstrated that CCDC106 expression correlates with advanced TNM stage (P = 0.008), positive regional lymph node metastasis (P < 0.001), and poor overall survival (P < 0.001) in 183 non-small cell lung… CONTINUE READING