CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

@article{Degner2011CCCTCbindingF,
  title={CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.},
  author={Stephanie C. Degner and Jiyoti Verma-Gaur and Timothy P. Wong and Claudia Bossen and G. Michael Iverson and Ali Torkamani and Christian Vettermann and Yin C Lin and Zhongliang Ju and Danae Schulz and Caroline S Murre and Barbara K. Birshtein and Nicholas J. Schork and Mark S Schlissel and Roy J. Riblet and Cornelis Murre and Ann J. Feeney},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 23},
  pages={9566-71}
}
Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V(H) genes to be brought in proximity with D(H)-J(H) segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we hypothesized that CTCF may promote the contraction of the Igh locus. ChIP sequencing was performed on pro-B cells… CONTINUE READING
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