CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.

  title={CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.},
  author={Hui Ling and Riccardo Spizzo and Yaser Atlasi and Milena Sabrina Nicoloso and Masayoshi Shimizu and Roxana Simona Redis and Naohiro Nishida and Roberta Gaf{\'a} and Jian Song and Zhiyi Guo and Cristina Ivan and Elisa Barbarotto and Ingrid de Vries and Xinna Zhang and Manuela Ferracin and Mike Churchman and Janneke F van Galen and Berna H. Beverloo and Maryam Shariati and Franziska Haderk and Marcos Roberto H Est{\'e}cio and Guillermo Garcia-Manero and Gijs A. Patijn and David C. Gotley and Vikas Bhardwaj and Imad Shureiqi and Subrata Sen and Asha S Multani and James Welsh and Ken Yamamoto and Itsuki Taniguchi and M Song and Steven Gallinger and Graham Casey and Stephen N. Thibodeau and Lo{\"i}c Le Marchand and Maarit Tiirikainen and Sendurai Mani and Wei Zhang and Ramana V. Davuluri and Koshi Mimori and Masaki Mori and Anieta M. Sieuwerts and John W. M. Martens and Ian Tomlinson and Massimo Negrini and Ioana Berindan-Neagoe and John A. Foekens and Stanley R. Hamilton and Giovanni Lanza and Scott Kopetz and Riccardo Fodde and George A. Calin},
  journal={Genome research},
  volume={23 9},
The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR-17-5p, and miR-20a are up-regulated by CCAT2 through TCF7L2-mediated transcriptional regulation. We further identify… CONTINUE READING
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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

  • MM Pomerantz, N Ahmadiyeh, +7 authors M Davis
  • Nat Genet
  • 2009
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