CCAT: Combinatorial Code Analysis Tool for transcriptional regulation

@inproceedings{Jiang2014CCATCC,
  title={CCAT: Combinatorial Code Analysis Tool for transcriptional regulation},
  author={Peng Jiang and Mona Singh},
  booktitle={Nucleic acids research},
  year={2014}
}
Combinatorial interplay among transcription factors (TFs) is an important mechanism by which transcriptional regulatory specificity is achieved. However, despite the increasing number of TFs for which either binding specificities or genome-wide occupancy data are known, knowledge about cooperativity between TFs remains limited. To address this, we developed a computational framework for predicting genome-wide co-binding between TFs (CCAT, Combinatorial Code Analysis Tool), and applied it to… CONTINUE READING
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