CCAAT binding transcription factor binds and regulates human COL1A1 promoter activity in human dermal fibroblasts: demonstration of increased binding in systemic sclerosis fibroblasts.

@article{Saitta2000CCAATBT,
  title={CCAAT binding transcription factor binds and regulates human COL1A1 promoter activity in human dermal fibroblasts: demonstration of increased binding in systemic sclerosis fibroblasts.},
  author={Biagio Saitta and Svetlana Gaidarova and Lucia Cicchillitti and Sergio A Jimenez},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 10},
  pages={2219-29}
}
OBJECTIVE To determine the binding factors that interact with the proximal promoter region of the human type I collagen gene, COL1A1, and to examine their involvement in its transcriptional regulation in normal and systemic sclerosis (SSc) dermal fibroblasts. METHODS Nuclear extracts from dermal fibroblasts from 4 patients with SSc and 4 age- and sex-matched control individuals were examined by electrophoresis mobility shift assays with a COL1A1 promoter fragment encompassing nucleotides -174… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Matrix remodeling in systemic sclerosis

Seminars in Immunopathology • 2015
View 3 Excerpts
Highly Influenced

The polymorphism of type 1 collagen (COL1A1) gene does not correlate with an increased risk of foot ulcers in patients with diabetes mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association • 2015

Similar Papers

Loading similar papers…