CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells.

@article{Ko2012CCAATenhancerBP,
  title={CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells.},
  author={Chiung-Yuan Ko and Ling-Hua Chang and Yi-Chao Lee and Esta Sterneck and Chun-Pei Cheng and Shunhua Chen and A Huang and Joseph T. Tseng and J Wang},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 2},
  pages={422.e11-25}
}
The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many inflammation-related diseases, suggesting that CEBPD and its downstream targets may play central roles in these conditions. Neuropathological studies show that a neuroinflammatory response parallels the early stages of Alzheimer's disease (AD). However, the precise mechanistic correlation between inflammation and AD pathogenesis remains unclear. CEBPD is upregulated in the astrocytes of AD patients. Therefore… CONTINUE READING