CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes.

@article{Kimura2001CCAATenhancerbindingPB,
  title={CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes.},
  author={Takemi Kimura and Shoaib Chowdhury and Toshiyuki Tanaka and Akane Shimizu and Katsuro Iwase and Seiichi Oyadomari and Tomomi Gotoh and Hiromitsu Matsuzaki and Masataka Mori and Shizuo Akira and Masaki Takiguchi},
  journal={FEBS letters},
  year={2001},
  volume={494 1-2},
  pages={105-11}
}
Transcription of genes for enzymes of the ornithine cycle is activated by hormones such as glucocorticoids and glucagon. Promoters and enhancers of several genes for the enzymes interact with the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors, and C/EBPbeta has been suggested to mediate glucocorticoid response of the gene for arginase, the last enzyme of the cycle. To determine the contribution of C/EBPbeta to hormonal regulation of genes for ornithine cycle enzymes, we… CONTINUE READING

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