CCAAT/enhancer binding protein beta (C/EBPβ)-2 transforms normal mammary epithelial cells and induces epithelial to mesenchymal transition in culture

@article{Bundy2003CCAATenhancerBP,
  title={CCAAT/enhancer binding protein beta (C/EBPβ)-2 transforms normal mammary epithelial cells and induces epithelial to mesenchymal transition in culture},
  author={Linda M. Bundy and Linda J Sealy},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={869-883}
}

• Linda M. Bundy, Linda J Sealy
• Published 2003 in Oncogene
• DOI:10.1038/sj.onc.1206216

The transcription factor CCAAT/enhancer binding protein (C/EBP)β is critical for normal growth and differentiation of the mammary gland. The intronless C/EBPβ gene encodes a single mRNA that produces three protein isoforms, C/EBPβ-1, -2, and -3, which share a common basic-leucine zipper domain at their C-terminus, but are distinguished at their N-termini by the in-frame methionine codon used to initiate translation. Although C/EBPβ-1 and -2 are both transactivators, they likely perform distinct… CONTINUE READING

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