CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma.

@article{Tan2005CCAATenhancerBP,
  title={CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma.},
  author={Ee Hong Tan and Shing Chuan Hooi and Mirtha Laban and Esther C. T. Wong and Sathivel Ponniah and Aileen Wee and Nai-dy Wang},
  journal={Cancer research},
  year={2005},
  volume={65 22},
  pages={10330-7}
}
The CCAAT/enhancer binding protein alpha (C/EBPalpha) is vital for establishing normal hepatic energy homeostasis and moderating hepatocellular growth. CEBPA loss-of-function mutations identified in acute myeloid leukemia patients support a tumor suppressor role for C/EBPalpha. Recent work showed reductions of C/EBPalpha levels in human hepatocellular… CONTINUE READING