CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma.

@article{Hsiao2013CCAATenhancerBP,
  title={CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma.},
  author={Yu-Wei Hsiao and C. Li and Jhih-Ying Chi and Joseph T. Tseng and Yao Fu Chang and L J Hsu and Chien-Hsun Lee and Tsung-Hao Chang and Shao-ming Wang and Dennis Ding Hwa Wang and Hung-Chi Cheng and J Wang},
  journal={Science signaling},
  year={2013},
  volume={6 284},
  pages={ra59}
}
Although tumors tend to be associated with immune cells and inflammation, this immune response often fails to eliminate the cancer and instead promotes cancer progression. Tumor-associated macrophages (TAMs) fail to phagocytose tumor cells, and they also produce signals that suppress the adaptive immune response. We showed that immunosuppressive prostaglandin E₂ (PGE₂) led to the production and activity of the transcription factor CCAAT/enhancer binding protein δ (C/EBPδ) by stimulating the… CONTINUE READING
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