CCAAT/Enhancer binding protein beta abrogates retinoic acid-induced osteoblast differentiation via repression of Runx2 transcription.

@article{WiperBergeron2007CCAATEnhancerBP,
  title={CCAAT/Enhancer binding protein beta abrogates retinoic acid-induced osteoblast differentiation via repression of Runx2 transcription.},
  author={Nadine Wiper-Bergeron and Catherine St-Louis and Jonathan M. Lee},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 9},
  pages={2124-35}
}
Runx2/CBFA1/AML3 is a master regulator of the osteoblast lineage and has been shown to directly control the transcription of numerous osteoblast-specific genes including alkaline phosphatase, osteopontin, and type I collagen. In its absence, ossification does not occur during development resulting in animals with cartilaginous skeletons and no osteoblasts. In humans, loss of one copy of Runx2 causes cleidocranial dysplasia characterized by malformations of the facial and cranial bones and the… CONTINUE READING
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