CCAAT/Enhancer Binding Protein Beta is Expressed in Satellite Cells and Controls Myogenesis

@article{Marchildon2012CCAATEnhancerBP,
  title={CCAAT/Enhancer Binding Protein Beta is Expressed in Satellite Cells and Controls Myogenesis},
  author={F. Marchildon and Neena Lala and G. Li and C. St-Louis and Daniel Lamothe and C. Keller and N. Wiper-Bergeron},
  journal={STEM CELLS},
  year={2012},
  volume={30}
}
Upon injury, muscle satellite cells become activated and produce skeletal muscle precursors that engage in myogenesis. We demonstrate that the transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in the satellite cells of healthy muscle. C/EBPβ expression is regulated during myogenesis such that C/EBPβ is rapidly and massively downregulated upon induction to differentiate. Furthermore, persistent expression of C/EBPβ in myoblasts potently inhibits differentiation at… Expand
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