CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation.

  title={CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation.},
  author={Vivian Chen and Emma Shtivelman},
  journal={Cell cycle},
  volume={9 24},
CC3/TIP30 is a metastasis and tumor suppressor, with reduced or absent expression in a variety of aggressive tumors. Overexpression of CC3 in tumor cells predisposes them to apoptosis in response to different death signals. We found that silencing of CC3 expression does not increase apoptotic resistance of cells. However, it strongly improves survival of tumor cells in response to glucose limitation. HeLa cells with silenced CC3 survive long-term in low glucose, and, in comparison to control… CONTINUE READING

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