CC chemokines induce the generation of killer cells from CD56+ cells

  title={CC chemokines induce the generation of killer cells from CD56+ cells},
  author={Azzam A. Maghazachi and Ala Al‐Aoukaty and Thomas J. Schall},
  journal={European Journal of Immunology},
We describe here that members of the CC chemokines exhibit biological activities other than chemotaxis. Macrophage inflammatory protein (MIP)‐1α, MIP‐1β, monocyte chemoattractant protein‐1 and RANTES, but not interleukin (IL)‐8, induce the generation of cytolytic cells, designated here as CHAK (CC chemokine‐activated killer) cells to distinguish them from IL‐2‐activated (LAK) cells. Like IL‐2, CC chemokines can induce the proliferation and activation of killer cells. While incubating CC… 

Chemokines, G proteins and natural killer cells.

  • A. Maghazachi
  • Biology, Chemistry
    Archivum immunologiae et therapiae experimentalis
  • 2000
The ability of members of chemokines to inhibit the replication of HIV-1 strains, combined with the ability of the same chemokine to activate the anti-viral NK cells, provide compelling evidence for the role of NK cells in eradicating HIV- 1 infection.

Role of chemokines in the biology of natural killer cells.

  • A. Maghazachi
  • Biology, Medicine
    Current topics in microbiology and immunology
  • 2010
Depending on the tissue and the chemokine secreted, NK cells may ameliorate the disease such as their roles in combating tumors or virally infected cells, and their therapeutic potentials in treating leukemias and other hematological malignancies, as well as reducing the incidence of GvH disease.

Chemokines activate natural killer cells through heterotrimeric G‐proteins: implications for the treatment of AIDS and cancer

  • A. MaghazachiA. Al‐Aoukaty
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1998
It is suggested that NK cells can be used to maximize the immunotherapeutic protocols for AIDS and cancer patients by activating members of the heterotrimeric G‐proteins.

Role of chemokines in the biology of natural killer cells

  • M. Robertson
  • Biology, Medicine
    Journal of leukocyte biology
  • 2002
NK cells participate in the in vivo rejection of transduced tumor cells that produce CCL19 or CCL21, and chemokines appear to play an important role in afferent and efferent NK cellresponses to infected and neoplastic cells.

Expression and regulation of chemokine receptors in human natural killer cells.

This study examined the expression of chemokine receptors in nonactivated natural killer (NK) cells and compared this expression with NK cells activated with interleukin (IL)-2, which either adhered to plastic flasks (AD) or did not adhere (NA).

Chemokine biology of NK cells and γδ T cells

Natural killer (NK) cells and γδ T cells are populations of lymphocytes that mediate immunity against pathogens and malignant tumors, and share the expression of cellular receptors (generally designated NK receptors) for the detection of MHC class I and class Ib proteins and other cell surface proteins.

Recombinant guinea pig CCL5 (RANTES) differentially modulates cytokine production in alveolar and peritoneal macrophages

A role for CCL5 in macrophage activation in addition to chemotactic properties is suggested and a role in regulating the inflammatory response to LPS in the guinea pig is suggested by modulating the production of proinflammatory cytokines by macrophages.

NK cells are migrated and indispensable in the anti-tumor activity induced by CCL27 gene therapy

Experiments using spleen cell fractionation and RT-PCR showed CCL27 receptor, mCCR10, was strongly expressed in NK cells, suggesting the accumulation of NK cells in tumor was attributed to chemoattractant activity of CCL 27 itself.

G protein‐coupled receptors in natural killer cells

Gaining knowledge regarding the distribution of activated NK cells toward the sites of tumor growth or virally infected sites will give an advantage in designing strategies using these cells as tools for the prevention and treatment of immunodeficiencies.

Regulation of human natural killer cell migration and proliferation by the exodus subfamily of CC chemokines.

Results of modified checkerboard assays indicate that Exodus-2 and -3 can participate in the recruitment and proliferation of activated NK cells and may regulate interactions between T cells and NK cells that are crucial for the generation of optimal immune responses.



Induction of natural killer cell migration by monocyte chemotactic protein−1, −2 and −3

Investigation of the responsiveness of NK cells to the prototypic C‐C chemokine, monocyte chemotactic protein‐1 (MCP‐1) found that it induced migration across filters of interleukin (IL)‐2‐activated NK cells, whereas it was a weak attractant for unstimulated cells.

RANTES and related chemokines activate human basophil granulocytes through different G protein‐coupled receptors

All CC‐chemokines except MIP‐lβ induced a similar rapid and transient rise of [Ca2+]| that was sensitive to pertussis toxin, indicating that they activate basophils via G‐protein‐coupled receptors.

Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta

Results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response, and enhance the ability of T cells to bind to an endothelial cell monolayer.

RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes

RANTES and MIP-1 alpha are crucial mediators of inflammatory processes in which eosinophils predominate, with kinetics similar to those induced by chemotactic peptides known to interact with G protein-coupled receptors.

C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells. Role for G proteins.

The differential inhibitory activity of CT and PT suggests that C-C chemokine receptors are coupled to different G proteins in IANK cells.

Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes

It is shown that two molecules in the chemokine (for chemoattractant cytokine) superfamily, human macrophage inflammatory protein 1 alpha (MIP-1 alpha) and Mip-1 beta, do not share identical attractant activities for lymphocyte subpopulations.

Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells

It is demonstrated that the IP-10 gene encodes for an inflammatory mediator that specifically stimulates the directional migration of T cells and monocytes as well as potentiates T cell adhesion to endothelium.

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

IL-12 can directly influence NK cell activities in purified CD56+ cells, and endogenously produced TNF-alpha is involved in mediating the effects of both IL-12 and IL-7.

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

Natural killer cell stimulatory factor may play an important role in the regulation of human NK cell function, and its possible use as a therapeutic cytokine deserves further investigation.