CC chemokines induce the generation of killer cells from CD56+ cells

@article{Maghazachi1996CCCI,
  title={CC chemokines induce the generation of killer cells from CD56+ cells},
  author={Azzam A. Maghazachi and Ala Al‐Aoukaty and Thomas J. Schall},
  journal={European Journal of Immunology},
  year={1996},
  volume={26}
}
We describe here that members of the CC chemokines exhibit biological activities other than chemotaxis. Macrophage inflammatory protein (MIP)‐1α, MIP‐1β, monocyte chemoattractant protein‐1 and RANTES, but not interleukin (IL)‐8, induce the generation of cytolytic cells, designated here as CHAK (CC chemokine‐activated killer) cells to distinguish them from IL‐2‐activated (LAK) cells. Like IL‐2, CC chemokines can induce the proliferation and activation of killer cells. While incubating CC… 

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References

SHOWING 1-10 OF 21 REFERENCES

Induction of natural killer cell migration by monocyte chemotactic protein−1, −2 and −3

TLDR
Investigation of the responsiveness of NK cells to the prototypic C‐C chemokine, monocyte chemotactic protein‐1 (MCP‐1) found that it induced migration across filters of interleukin (IL)‐2‐activated NK cells, whereas it was a weak attractant for unstimulated cells.

RANTES and related chemokines activate human basophil granulocytes through different G protein‐coupled receptors

TLDR
All CC‐chemokines except MIP‐lβ induced a similar rapid and transient rise of [Ca2+]| that was sensitive to pertussis toxin, indicating that they activate basophils via G‐protein‐coupled receptors.

Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta

TLDR
Results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response, and enhance the ability of T cells to bind to an endothelial cell monolayer.

RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes

TLDR
RANTES and MIP-1 alpha are crucial mediators of inflammatory processes in which eosinophils predominate, with kinetics similar to those induced by chemotactic peptides known to interact with G protein-coupled receptors.

C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells. Role for G proteins.

TLDR
The differential inhibitory activity of CT and PT suggests that C-C chemokine receptors are coupled to different G proteins in IANK cells.

Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes

TLDR
It is shown that two molecules in the chemokine (for chemoattractant cytokine) superfamily, human macrophage inflammatory protein 1 alpha (MIP-1 alpha) and Mip-1 beta, do not share identical attractant activities for lymphocyte subpopulations.

Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells

TLDR
It is demonstrated that the IP-10 gene encodes for an inflammatory mediator that specifically stimulates the directional migration of T cells and monocytes as well as potentiates T cell adhesion to endothelium.

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

TLDR
IL-12 can directly influence NK cell activities in purified CD56+ cells, and endogenously produced TNF-alpha is involved in mediating the effects of both IL-12 and IL-7.

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

TLDR
Natural killer cell stimulatory factor may play an important role in the regulation of human NK cell function, and its possible use as a therapeutic cytokine deserves further investigation.