CC-chemokine receptor 3: a possible target in treatment of allergy-related corneal ulcer.

@article{Fukagawa2002CCchemokineR3,
  title={CC-chemokine receptor 3: a possible target in treatment of allergy-related corneal ulcer.},
  author={Kazumi Fukagawa and Naoko Okada and Hiroshi Fujishima and Toshiharu Nakajima and Kazuo Tsubota and Yoji Takano and Hiroshi Kawasaki and Hirohisa Saito and Koichi Hirai},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 1},
  pages={58-62}
}
PURPOSE To determine the suppressive effects of antibodies (Abs) against CC-chemokine receptor (CCR)-1 and CCR-3 on eosinophil chemotaxis induced by culture supernatant from corneal keratocytes and by tears from severely allergic patients with corneal ulcer. METHODS Primary cultures of human corneal keratocytes were incubated with interleukin (IL)-4 (33.3 ng/mL) and tumor necrosis factor (TNF)-alpha (33.3 ng/mL) for 48 hours. In tear samples collected from five severely allergic patients and… CONTINUE READING
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